N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide
N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide
CAS: 423145-35-1
Molecular Formula: C21H19ClN2O4
N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide - Names and Identifiers
N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide - Physico-chemical Properties
| Molecular Formula | C21H19ClN2O4 |
| Molar Mass | 398.84 |
| Solubility | DMSO |
| Storage Condition | −20℃ |
| Use | YUM70 is a potent inhibitor of GRP78 (Glucose-regulated protein, 78 kDa). YUM70, inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis. A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER. Moreover, a YUM70-PROTAC (PROteolysis TArgeting Chimera) was synthesized to force degradation of GRP78 in pancreatic cancer cells. YUM70 showed a strong synergistic cytotoxicity with topotecan and vorinostat. |
N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide - Reference
| Reference Show more | Samanta S, Yang S, Debnath B, Xue D, Kuang Y, Ramkumar K, Lee AS, Ljungman M, Neamati N. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2:canres.1540.2020. doi: 10.1158/0008-5472.CAN-20-1540. Epub ahead of print. PMID: 33531374. |
N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.507 ml | 12.536 ml | 25.073 ml |
| 5 mM | 0.501 ml | 2.507 ml | 5.015 ml |
| 10 mM | 0.251 ml | 1.254 ml | 2.507 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.501 ml |
Last Update：2024-01-02 23:10:35
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Product Name: N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide Visit Supplier Webpage Request for quotation
CAS: 423145-35-1
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 423145-35-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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